A proven leader in the market

a proven leader in the market

 

Unparalleled accuracy for trisomy 21 and fetal sex

unparalleled accuracy for trisomy 21 and fetal sex

Four known mosaic cases were included: two monosomy X, one T13, and one T18. Both cases of monosomy X were called high-risk, the T18 was called low-risk, and the T13 was no-called. False-positive and false-negatives can occur on all chromosomes due to maternal, fetal, and/or placental mosaicism or as a result of other causes.

Unparalleled accuracy for trisomy 21 and fetal sex

unparalleled accuracy for trisomy 21 and fetal sex

Four known mosaic cases were included: two monosomy X, one T13, and one T18. Both cases of monosomy X were called high-risk, the T18 was called low-risk, and the T13 was no-called. False-positive and false-negatives can occur on all chromosomes due to maternal, fetal, and/or placental mosaicism or as a result of other causes.

Unparalleled accuracy for trisomy 21 and fetal sex

unparalleled accuracy for trisomy 21 and fetal sex

Four known mosaic cases were included: two monosomy X, one T13, and one T18. Both cases of monosomy X were called high-risk, the T18 was called low-risk, and the T13 was no-called. False-positive and false-negatives can occur on all chromosomes due to maternal, fetal, and/or placental mosaicism or as a result of other causes.

Unparalleled accuracy for trisomy 21 and fetal sex

unparalleled accuracy for trisomy 21 and fetal sex

Four known mosaic cases were included: two monosomy X, one T13, and one T18. Both cases of monosomy X were called high-risk, the T18 was called low-risk, and the T13 was no-called. False-positive and false-negatives can occur on all chromosomes due to maternal, fetal, and/or placental mosaicism or as a result of other causes.

Panorama has the lowest false negative rate

  • Low fetal fraction is one of the most common causes of false negative results.
  • Panorama has the lowest false negative rate: 0.6% in published clinical trials.
  • Panorama measures fetal fraction and adjusts the algorithm accordingly,
    improving sensitivity, even at low fetal fractions.

panorama has the lowest false negative rate

Zero errors in fetal sex validation

  • Panorama is the only NIPT with zero incorrect fetal sex calls in validation studies.
  • With counting method NIPTs, as many as 1 in 77 cases may have gender discrepancy.

zero errors in fetal sex validation

Zero errors in fetal sex validation

  • Panorama is the only NIPT with zero incorrect fetal sex calls in validation studies.
  • With counting method NIPTs, as many as 1 in 77 cases may have gender discrepancy.

zero errors in fetal sex validation

Zero errors in fetal sex validation

  • Panorama is the only NIPT with zero incorrect fetal sex calls in validation studies.
  • With counting method NIPTs, as many as 1 in 77 cases may have gender discrepancy.

zero errors in fetal sex validation

Zero errors in fetal sex validation

  • Panorama is the only NIPT with zero incorrect fetal sex calls in validation studies.
  • With counting method NIPTs, as many as 1 in 77 cases may have gender discrepancy.

zero errors in fetal sex validation

1.       Nicolaides KH et al. Prenat Diagn. 2013 June;33(6):575-9.

2.       Pergament E et al. Obstet Gynecol. 2014 Aug;124(2 Pt 1):210-8.

3.       Ryan A et al. Fetal Diagn Ther. 2016;40(3):219-223.

4.       Nicolaides KH et al. Fetal Diagn Ther. 2014;35(3):212-7.

5.       Stokowski et al. Prenat Diagn. 2015 Oct; DOI: 10.1002/pd.4686.

6.       Palomaki, et al. Genet Med. 2011 Nov;13(11):913-20.

7.       Palomaki, et al. Genet Med. 2012 Mar;14(3):296-305.

8.       Porreco et al. Am J Obstet Gynecol 2014;210.

9.       Mazloom et al. Prenat Diagn 2013;33:591-7.

10.   Sehnert et al. MolecularDiagn and Gene 2011.

11.   Bianchi, et al. Obstet Gynecol. 2012 May;119(5):890-901.

12.   Bianchi et al. N Engl J Med 2014;370:799-808.

13.   Verinata white paper. Analytical validation of the Verifi prenatal test. 2012.

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